The Obs & Gyn Hospital of Fudan University was built in 1884.In the hospital, the menstrual disorder clinic and endocrine laboratory were established in 1953, which gradually evolved into a subspecialty of gynecology-gynecological endocrinology, with a WHO-standard endocrine testing laboratory which developed to Maternity Institute in 1974. In 1975, reproductive endocrinology wards were opened which had 30 specialist beds. In 1997, an integrated endocrine specialist clinic-ward-laboratory diagnosis and treatment system was set up, names as "Shanghai female reproductive endocrinal diagnosis and treatment center ".
Currently, the gyn-endo ward contains 29 specialist beds, while monthly outpatients stabilize 300 to 450, closed to 10% of gynecology clinic. In recent five years, the endocrine clinic visits take up to 3100-3500 per year. Arranging senior doctors in clinic from Monday to Friday and organizing consultation in difficult cases are keys to ensure treatment quality. Approximately 300 cases across the country who suffered from complicated gynecological endocrine diseases come to our center for consultation every year.
The involved areas of reproductive endocrinology clinics includes problems caused by endocrine disorders in every life stage of women, such as precocious puberty, delayed sexual development, sexual differentiation abnormalities (including gonadal dysgenesis, 46XY DSD and eggs-testicle-type DSD,etc.), female reproductive tract abnormalities, amenorrhea, hyper-androgenism, polycystic ovary syndrome, hyper-prolactinemia, dysfunctional uterine bleeding, menorrhagia and oligomenorrhea, dysmenorrhea, premenstrual syndrome, congenital adrenal hyperplasia, peri-menopausal and postmenopausal hormone therapy and hormone-dependent gynecological disease, all-kins-infertility, menopausal syndrome and endocrine disorders with pregnancy. Among all the above, we are especially good at: polycystic ovary syndrome, delayed puberty and sexual differentiation abnormality, dysfunctional uterine bleeding, all-kinds-amenorrhea. Some domestically and abroad recognized difficult pathology such as ovarian failure, hyper-prolactinemia, and weight loss - anorexia nervosa amenorrhea are partially recovered through the introduction of new treatment methods. Some of ovarian failure case got healthy offspring, while most hyper-prolactinemia avoid craniotomy, and weight loss - anorexia nervosa has recovered menses and nervosa had also been improved. In patients with adenomyosis, GnRH-a adding adenosis lesions resection and tubal angioplasty make a lot of patients pregnant. PCOS suffered progesterone resistant endometrial proliferative diseases but refuses or is not proper for surgical treatment can be successful transformed by drugs, by which reproductive function can be retained. In the treatment of various infertility and recurrent miscarriage effect has been remarkable improved through the endocrine reatment. Meanwhile, through individualized programs, postmenopausal symptoms such as low postmenopausal estrogen symptoms, genitourinary atrophy symptoms, and osteoporosis have been effectively alleviated, with side effects avoided or reduced.
The inpatients of endocrine ward reaches 1200-1530 per year, among which are 150-250 infertile patients. Operations reach to an average of 660-1300 patients per year, of which the average rate of endoscopic minimally invasive surgery is 66%. Tubal infertile surgery takes about 400 cases per year. Apart from this, 20 MRKH cases have been done vaginoplasty every year, and 10 cases congenital adrenal hyperplasia patients with genital plastic surgery, while about 10 cases 46XY DSD with gonadal line resection. In polycystic ovary syndrome, ovulation rate after surgery is 97% and pregnancy rate 92%. Contemporarily, post-operative pregnancy rate was 80% in formation of tubal umbrella end and 70-90% in pelvic endometriosis, which reached the international advanced level.
In order to break clinical problem and improve the quality of clinical treatment, research of our center mainly inclined to the multiple, difficult disease. Gyn-Endo center has accessed a series of National Natural Science Foundation, National Eleventh Five-Year Science and Technology Commission from Ministry of Science and Technology Support Program, and Shanghai Natural Science Fund.
To promote scientific research, resulting in greater social benefits, our center firstly open national continuing education programs, including "National Sessions on progress in diagnosis and treatment of female reproductive endocrinology ", and "National Sessions on progress in polycystic ovary syndrome" and "National Sessions on progress in endoscopic diagnosis and treatment", training technical specialist and revise female reproductive endocrine diseases treatment practices, all of which could result a great contribution to the development of the reproductive endocrinology subject.